Antioch on the Orontes (Latin: Antiochia ad Orontem; also Great Antioch or Syrian Antioch; Arabic:انطاکیه) was an ancient city on the eastern side of the Orontes River. It is near the modern city of Antakya, Turkey.

Founded near the end of the 4th century BC by Seleucus I Nicator, one of Alexander the Great's generals, Antioch eventually rivaled Alexandria as the chief city of the Near East and was a cradle of gentile Christianity. It was one of the four cities of the Syrian tetrapolis. Its residents were known as Antiochenes.