Vesta was the virgin goddess of the hearth, home, and family in Roman religion. Vesta's presence was symbolized by the sacred fire that burned at her hearth and temples.

Vesta's (in some versions she is called Vestia) fire was guarded at her Temples by her priestesses, the Vestales. Every March 1 the fire was renewed. It burned until 391, when the Emperor Theodosius I forbade public pagan worship. One of the Vestales mentioned in mythology was Rhea Silvia, who with the God Mars conceived Romulus and Remus (see founding of Rome).

The Vestales were one of the few full-time clergy positions in Roman religion. They were drawn from the patrician class and had to observe absolute chastity for 30 years. It was from this that the Vestales were named the Vestal virgins. They could not show excessive care of their person, and they were not allowed to let the fire go out. The Vestal Virgins lived together in a house near the Forum (Atrium Vestae), supervised by the Pontifex Maximus. On becoming a priestess, a Vestal Virgin was legally emancipated from her father's authority and swore a vow of chastity for 30 years. This vow was so sacred that if it were broken, the Vestal was buried alive in the Campus Sceleris ('Field of Wickedness'). It is likely that this is what happened to Rhea Silvia. They were also very independent and had many privileges that normal women did not have. They could move around the city but had to be in a carriage.

The Vestales had a strict relationship with the rex sacrorum and flamen dialis as is shown in the verses of Ovid about their taking the februae (lanas: woolen threads) from the king and the flamen. Their relationship with the king is also apparent in the ritual phrase: "Vigilasne rex, vigila!" by which they apostrophated him. The sacrality of their functions is well compounded by Cicero's opinion that without them Rome could not exist as it would not be able to keep contact with gods.

A peculiar duty of the vestals was the preparation and conservation of the sacred salamoia muries used for the savouring of the mola or mola salsa, dough to be spread on sacrificial victims, a procedure known as immolation. This dough too was prepared by them on fixed days. Theirs also the task of preparing the suffimen for the Parilia.